2018年　IAAO

Theme：Quantum Leap to Next Horizon in Cancer Research and Therapy

Opening Remarks

Osamu Nagayama, Chairman Chugai Academy for Advanced Oncology

1. Next Horizon in Cancer Research and Therapy

▶ Expanding Horizons for Cancer Genomics

Speaker: Speaker: Bruce A. Chabner (Harvard Medical School, USA) Chair/Moderator: Makoto Ogawa (Aichi Cancer Center, Japan)

2. Breakthroughs in Cancer Immunotherapy

▶ Neoantigens and the Molecular Basis of Personalized Cancer Immunotherapy

Speaker: Robert D. Schreiber (Washington University School of Medicine, USA) Chair/Moderator: Ryuzo Ueda (Aichi Medical University, Japan)

▶ Mechanistic Basis of Cancer Immunotherapy

Speaker: Ira Mellman (Genentech Inc., USA) Chair/Moderator: Yuko Kitagawa (Keio University, Japan)

▶ Deconvolution of Cellular Determinants of Anti-Tumor Immune Responses

Speaker: Ash A. Alizadeh (Stanford School of Medicine, USA) Chair/Moderator: Nagahiro Saijo (Akihabara Medical Clinic, Japan)

3. New Insights in Target Discovery and Resistance

▶ Complex Functional Analysis is Required for Optimizing Targeted Therapy.

Speaker: Neal Rosen (Memorial Sloan Kettering Cancer Center, USA) Chair/Moderator: Kiyohiko Hatake (International University of Health and Welfare, Japan)

▶ Discovery of a New Class of Oncogenic Drivers in Breast Cancer

Speaker: Leif W. Ellisen (Harvard Medical School, USA) Chair/Moderator: Mitsuaki Yoshida (Japanese Foundation For Cancer Research, Japan)

▶ Inflammatory Breast Cancer Biology; the Tumor Microenvironment is the Key

Speaker: Naoto T. Ueno (The University of Texas MD Anderson Cancer Center, USA) Chair/Moderator: Masakazu Toi (Kyoto University, Japan)

4. Progress in Precision Oncology

▶ The Genomic Landscape of Advanced Hormone Resistant Breast Cancer

Speaker: José Baselga (Memorial Sloan Kettering Cancer Center, USA) Chair/Moderator: Chikashi Ishioka (Tohoku University, Japan)

▶ The Era of Genome Driven Oncology: Making the Clinic the New Laboratory

Speaker: David M. Hyman (Memorial Sloan Kettering Cancer Center, USA) Chair/Moderator: Yasuhiro Fujiwara (National Cancer Center, Japan)

▶ Tumor Evolution and Heterogeneity in Oncogene-Driven Lung Cancers

Speaker: Alice T. Shaw (Harvard Medical School, USA) Chair/Moderator: Kohei Miyazono (The University of Tokyo, Japan)

5. Advances in Cancer Genomics / Genetics

▶ Chromosomal Order from Chaos in Cancer Evolution, Immune Escape and Metastases : TRACERx

Speaker: Charles Swanton (The Francis Crick Institute, UK) Chair/Moderator: Hiroyuki Aburatani (The University of Tokyo, Japan)

▶ Holistic View of Cancer Genomics in GI Area

Speaker: Josep Tabernero (The Vall d’ Herbron University Hospital, Spain) Chair/Moderator: Atsushi Ohtsu (National Cancer Center, Japan)

▶ A One-Two Punch Model for Cancer Therapy
-Exploiting Powerful Sequential Combinations by Functional Genetics

Speaker: René Bernards (Netherlands Cancer Institute, Netherlands) Chair/Moderator: Hiroyuki Mano (National Cancer Center Research Institute, Japan)

▶ Liver Cancer Progression and Wnt Signaling

Speaker: Hiroyuki Aburatani (The University of Tokyo, Japan) Chair/Moderator: Charles Swanton (The Francis Crick Institute, UK)

Closing Remarks

Josep Tabernero The Vall d’ Herbron University Hospital, Spain